Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes

IL-1R-associated kinase-1 mediates protein kinase Cδ-induced IL-1β production in monocytes.

The role of IL-1R-associated kinase (IRAK)1 and its interaction with protein kinase C (PKC)δ in monocytes to regulate IL-1β production has not been reported so far. The present study thus investigates such mechanisms in the THP1 cell line and human monocytes. PMA treatment to THP1 cells induced CD11b, TLR2, TLR4, CD36, IRAK1, IRAK3, and IRAK4 expression, IRAK1 kinase activity, PKCδ and JNK phos...

Protein kinase Cδ in tumorigenesis of human malignant fibrous histiocytoma.

Protein kinase Cδ (PKCδ), an isoform of PKC, has been shown to act as a critical mediator of tumor progression and apoptosis; however, its role in musculoskeletal tumors is still unknown. In the current study, we examined the expression of PKCδ in human musculoskeletal tumor tissue samples, and investigated the effects of siRNA downregulation of PKCδ on human malignant fibrous histiocytoma (MFH...

B-cell Signaling: Protein Kinase Cδ Puts the Brakes on

Protein kinase C (PKC) is one of the cell’s most important signal-transducing molecules, responding to a diversity of extracellular cues to regulate a number of central processes, including proliferation, metabolism, migration and death [1]. It is also one of the more complex signal transducers, constituting a family of serine/threonine kinases that can phosphorylate a multitude of cellular sub...

Is human dectin-1 Y238X gene polymorphism related to susceptibility to recurrent vulvovaginal candidiasis?

Background and Purpose: Vulvovaginal candidiasis is a frequent disease affecting approximately more than %75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic Candida species. Recurrent vulvovaginal candidiasis (RVVC) is common in otherwise healthy individuals. Several risk factors were reported to contribute to RVVC susceptibility. A polymorphism in Decti...

Kinase Signaling Phagosomes via Targeting Dectin-1/Syk Aspergillus fumigatus Recruitment in Corticosteroids Block Autophagy Protein